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Tumor doubling time and local immune response to hepatic metastases from colorectal cancer
Author(s) -
Kito Ayako,
Tanaka Kuniya,
Fujimaki Haruka,
Nakazawa Masatoshi,
Togo Shinji,
Minami Mutsuhiko,
Shimada Hiroshi
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20806
Subject(s) - colorectal cancer , immune system , medicine , cd8 , proliferating cell nuclear antigen , flow cytometry , metastasis , cancer , cancer research , immunohistochemistry , t cell , pathology , immunology
Background and objectives A number of studies have investigated the role of tumor‐infiltrating lymphocytes in cancer, yet the local immune response to hepatic colorectal cancer metastasis remains unclear. As the tumor doubling time (DT) of hepatic colorectal cancer metastases is a good index of tumor growth, we examined the correlation between tumor DT and the local immune response by phenotype in hepatic colorectal cancer metastases. Methods Tumor DT and local immune response were examined in 20 patients with hepatic colorectal cancer metastases by analyzing tumor‐infiltrating lymphocytes using flow cytometry or immunohistochemical studies. Tumor proliferative activity was also investigated by determining the expression levels of Ki‐67 and proliferating cell nuclear antigen (PCNA). Results Locally abundant populations of CD83 + dendritic cells (DCs) and CD8 + T cells were positively related to longer tumor DT ( P < 0.05), as were abundant CD8 + T cells having interferon‐γ‐producing potentials ( P < 0.05). There was no significant correlation between tumor cell expression levels of Ki‐67 or PCNA and tumor DT. Conclusions Longer DT tumors have increased local populations of CD8 + T cells and CD83 + DCs even in hepatic colorectal cancer metastases. J. Surg. Oncol. 2007;96:525–533. © 2007 Wiley‐Liss, Inc.