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Prognostic impact of positive lymph node ratio in gastric carcinoma
Author(s) -
Celen Orhan,
Yildirim Emin,
Berberoglu Uğur
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20797
Subject(s) - medicine , hazard ratio , lymph node , multivariate analysis , oncology , lymph , proportional hazards model , cancer , univariate analysis , carcinoma , pathology , confidence interval
Background and objectives To evaluate the prognostic value of metastatic lymph node ratio in gastric carcinoma. Methods One hundred and sixty four patients who underwent D 2 dissection for gastric carcinoma at Ankara Oncology Hospital were reviewed retrospectively. The prognostic factors including Japanese classification, AJCC/UICC TNM classification and metastatic lymph node ratio (1–10% and >10%) were evaluated in univariate and multivariate Cox regression analysis. Results The multivariate analysis showed that Borrmann classification, pN–category of AJCC/UICC classification and metastatic lymph node ratio were the most significant prognostic factors and a higher hazard ratio was obtained for metastatic lymph node ratio than pN category of AJCC/UICC classification (4.5 vs. 11.4). When the metastatic ratio groups of 1–10% and >10% were subdivided into pN 1 , pN 2 and pN 3 categories of the AJCC/UICC classification, there was no statistical difference between survival curves. When pN 1 , pN 2 and pN 3 categories of the AJCC/UICC classification were subdivided into the ratio groups of 1–10% and >10%, the survival rate of ratio group 1–10% was better than ratio group >10%. Conclusion With its simplicity and reproducibility, metastatic lymph node ratio can be used as a reliable prognostic indicator. J. Surg. Oncol. 2007;96:95–101. © 2007 Wiley‐Liss, Inc.