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Clinical impact of the surgical margin status in hepatectomy for solitary mass‐forming type intrahepatic cholangiocarcinoma without lymph node metastases
Author(s) -
Shimada Kazuaki,
Sano Tsuyoshi,
Sakamoto Yoshihiro,
Esaki Minoru,
Kosuge Tomoo,
Ojima Hidenori
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20792
Subject(s) - medicine , surgical margin , lymph node , hepatectomy , intrahepatic cholangiocarcinoma , dissection (medical) , resection margin , overall survival , survival rate , lymph , margin (machine learning) , surgery , radiology , resection , pathology , machine learning , computer science
Background and Objectives The clinical impact of the surgical margin status in macroscopic curative hepatectomy for intrahepatic cholangiocarcinoma (ICC) has not yet been fully investigated. Methods The data of 57 consecutive patients with mass‐forming (MF) type ICC who underwent macroscopic curative hepatectomy during a 10‐year period were retrospectively examined, and the relationship between the surgical margin status and patient survival was analyzed. Results Lymph node metastases were found to be independently associated with poor survival. The overall 5‐year survival rates and the median survival term in the 38 patients without lymph node metastases were 56.8% and 62 months, respectively. Among these 38 patients, the survival rate was better in the negative surgical margin group as compared with that in the positive surgical margin group. However, there was no statistically significant difference between the narrow and wide surgical margin groups. Conclusions Negative surgical margin had a definite favorable impact on the survival of patients with a solitary ICC without lymph node metastases. Surgery should be conducted in patients without lymph node metastases even if a wide surgical margin cannot be obtained, but careful attention should be paid not to expose tumors during hepatic dissection. J. Surg. Oncol. 2007;96:160–165. © 2007 Wiley‐Liss, Inc.