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Incidence and prognostic values of lymph node metastasis in operable hepatocellular carcinoma and evaluation of routine complete lymphadenectomy
Author(s) -
Sun HuiChuan,
Zhuang PengYuan,
Qin LunXiu,
Ye QingHai,
Wang Lu,
Ren Ning,
Zhang JuBo,
Qian YongBing,
Lu Lu,
Fan Jia,
Tang ZhaoYou
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20772
Subject(s) - medicine , lymphadenectomy , incidence (geometry) , radiation therapy , hepatocellular carcinoma , lymph node , carcinoma , oncology , chemotherapy , surgery , gastroenterology , radiology , physics , optics
Background To study lymph node metastasis (LNM) and prognosis in patients with operable hepatocellular carcinoma (HCC) as well as the value of routine complete lymphadenectomy. Few studies have been reported on LNM in patients with operable HCC. Methods Lymph node enlargement of 968 patients with operable HCC was carefully explored and LNM was diagnosed by typical intraoperative findings or pathology. Results Forty‐nine (5.1%) patients had LNM, which was associated with advanced tumor properties. The 1‐, 3‐, and 5‐year overall survival in patients with LNM was poorer than those without LNM (62.0%, 31.0%, and 26.0% vs. 81.0%, 62.0%, and 47.0%, P = 0.000). The 1‐, 3‐, and 5‐year overall survival in patients who received complete lymphadenectomy (n = 26) was poorer than those without LNM (68.0%, 31.0%, and 31.0% vs. 81.0%, 62.0%, and 47.0%, P = 0.017), and was not better than patients who received chemotherapy or radiotherapy ( P = 0.944). Conclusion The incidence of LNM in operable HCC patients was low, and patients with LNM had a poorer prognosis. LNM status determined the disease‐free survival but not the overall survival of HCC. The complete lymphadenectomy did not improve overall survival, as compared with chemotherapy or radiotherapy. J. Surg. Oncol. 2007;96:37–45. © 2007 Wiley‐Liss, Inc.