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Feasibility of concurrent adjuvant chemotherapy and radiotherapy after breast‐conserving surgery in early breast cancer
Author(s) -
Han Sehwan,
Kim Juree,
Sohn Seungchang,
Kwak GeumHee,
Kim JiYoung,
Park Kyeongmee
Publication year - 2006
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20715
Subject(s) - medicine , breast cancer , radiation therapy , chemotherapy , adjuvant , breast conserving surgery , adverse effect , mammary gland , surgery , cancer , oncology , radiology , mastectomy
Background The optimal sequence of chemotherapy (CT) and radiotherapy (RT) remains uncertain after breast‐conserving surgery (BCS). The current study was performed to evaluate whether the concurrent RT with CT increases the toxicities. Methods Two hundred and thirty‐eight patients with stages I and II breast cancers were prospectively allocated to concurrent CT and RT (n = 133) and sequential CT and RT (n = 105) after BCS. In the sequential group, RT was started after the completion of three cycles of CT and additional three cycles of CT were delivered after RT. Results There was no significant difference in Grade 3 or 4 hematologic toxicities during CT between the two groups. Radiation related adverse effects were not different between the two groups. During the median follow‐up period of 42 months (range: 16–60 months), 18 patients (13.5%) of the concurrent group had systemic recurrence of breast cancer, whereas 20 patients (19.1%) of the sequential group had systemic recurrence. Disease‐free survival and local recurrence were not different between the two groups. Conclusions Concurrent CT and RT were not associated with increased toxicity and showed reasonable cosmetic results. The current study indicates that concurrent RT and CT after BCS is a feasible treatment modality with an advantage of shortening the treatment time. J. Surg. Oncol. 2007;95:45–50. © 2006 Wiley‐Liss, Inc.