Premium
Factors predictive for long‐term survival of male patients with hepatocellular carcinoma after curative resection
Author(s) -
Zhou Li,
Rui JingAn,
Wang ShaoBin,
Chen ShuGuang,
Qu Qiang,
Chi TianYi,
Wei Xue,
Han Kai,
Zhang Ning,
Zhao HaiTao
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20678
Subject(s) - medicine , hepatocellular carcinoma , multivariate analysis , survival analysis , oncology , univariate analysis , retrospective cohort study , proportional hazards model , gastroenterology , carcinoma , surgery
Background and Objectives Curative hepatic resection (CHR) was a modality that provides possibility of long‐term survival for hepatocellular carcinoma (HCC). So far, prognostic factors of male patients with HCC after CHR remain unclear. Purposes of the present study were to identify these factors and to compare them with those for females. Methods Consecutive 151 male and 23 female patients with HCC undergoing CHR were enrolled in this retrospective study. Their prognostic factors were identified by uni‐ and multi‐variate statistical analysis. Results One‐, three‐ and five‐year overall and disease‐free survival of male patients were 82.4, 51.5, and 43.6%, and 65.8, 33.7, and 21.7%, respectively, with no significant differences compared to females. Univariate analysis showed that tumor size, TNM staging, Edmondson‐Steiner grade, serum α‐fetoprotein (AFP) level, presence of portal vein tumor thrombosis (PVTT) and satellite nodule were significant for males with HCC, but only Edmondson‐Steiner grade, presence of PVTT and satellite nodule were independent. For females, Edmondson‐Steiner grade was the single potential indicator for survival. Conclusions Malignant degree and invasive phenotypes were main factors that independently influenced survival of male patients with HCC after CHR. Among them, histological grade, which was also potentially significant for females, was the most powerful survival predictor. J. Surg. Oncol. 2007;95:298–303. © 2007 Wiley‐Liss, Inc.