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Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity
Author(s) -
Tewari Mallika,
Rai Pramod,
Singh Gautam Bir,
Kumar Mohan,
Shukla Hari S.
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20677
Subject(s) - medicine , stage (stratigraphy) , nd:yag laser , surgery , carcinoma , leukoplakia , biopsy , malignancy , cancer , lesion , basal cell , laser , paleontology , physics , optics , biology
Background and Objectives Only few studies (none from India) have reported the role of Neodymium Yttrium‐Aluminum‐Garnet (Nd: YAG) laser for treatment of premalignant and stage I (T 1 N 0 M 0 ) oral cancer. This study aimed to assess the outcome of Nd: YAG laser in the said lesions after a follow‐up of 5 years. Design : Prospective study; Setting : a tertiary care hospital, North India. Patients and Methods Fifty biopsy proven patients of premalignant/malignant (Stage I) lesions oral cavity underwent Nd: YAG laser treatment after prior informed consent from January, 1997 to January, 2000. Patients were followed‐up for 5 years. In addition to local recurrence, patient's mucosal response to laser in terms of pain, mastication, salivation, paraesthesias, facial expressions, and speech was also recorded. Results Twenty‐seven patients had leukoplakia, 3 erythroplakia, 6 carcinoma in situ (CIS), and 14 stage I squamous cell carcinoma (SCC) of oral cavity. Four patients required repeat laserization for residual/ recurrent lesion and 15 patients were lost to follow‐up. Recurrence free survival (RFS) at 5‐years in premalignant and stage I SCC patients was 97.2 and 78.6%, respectively. A minimal persistent edema was observed in 6 (12%) patients at the end of 7th day, rest all tolerated the procedure well. Conclusions The present study indicates that Nd: YAG laser is an effective and safe surgical option management of premalignant and malignant lesions of oral cavity. J. Surg. Oncol. 2007;95:281–285. © 2007 Wiley‐Liss, Inc.