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Chemoradiotherapy followed by surgery for squamous cell carcinoma of the thoracic esophagus with clinical evidence of adjacent organ invasion
Author(s) -
de Manzoni Giovanni,
Pedrazzani Corrado,
Pasini Felice,
Bernini Marco,
Minicozzi Anna Maria,
Giacopuzzi Simone,
Grandinetti Antonio,
Cordiano Claudio
Publication year - 2007
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20640
Subject(s) - medicine , esophagus , surgery , carcinoma , chemoradiotherapy , esophagectomy , radiation therapy , survival rate , cardiothoracic surgery , esophageal cancer , cancer
Background The role of surgery for esophageal squamous cell carcinoma (SCC) with clinical evidence of adjacent organ invasion (cT4) is a debated issue. This study was aimed at analyzing our experience with chemoradiotherapy (CRT) followed by surgery as treatment for non‐metastatic cT4 SCC of the thoracic esophagus. Methods The results of 51 patients consecutively treated at the First Department of General Surgery, University of Verona, from January 1987 to December 2004 were analyzed. Results The most frequently clinically involved structures were the trachea (43.1%), the main left bronchus (17.6%), and the thoracic aorta (15.7%). CRT was completed in all but one of the patients (98.0%) without toxicity‐related deaths. After completion of induction treatment 49 patients underwent surgery (96.1%), and resection was possible in 40 patients (78.4%) but R0 surgery was rarely obtained (39.2%). Pathologic downstaging was achieved in 18 cases (35.3%) while a major response (responders) was observed in 10 patients (19.6%) and a complete response (pT0N0) in 7 (13.7%). The overall median survival time was 11.1 months with a 3‐year survival rate of 8.8%. A significantly better survival ( P < 0.001) was observed after a R0 resection (median: 22.3 months; 3‐year survival: 25.4%; P < 0.001) and for responders (median: 33.1 months; 3‐year survival: 25.7%; P = 0.019). Conclusions Aggressive multi‐modal therapy with CRT followed by surgery in cT4 SCC of the thoracic esophagus is feasible. Surgery should be limited to patients with significant response to induction treatment and a high probability of R0 resection. J. Surg. Oncol. 2007;95:261–266. © 2007 Wiley‐Liss, Inc.