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Increase in both CEA and CA19‐9 in sera is an independent prognostic indicator in colorectal carcinoma
Author(s) -
Nozoe Tadahiro,
Rikimaru Tatsuya,
Mori Emiko,
Okuyama Toshiro,
Takahashi Ikuo
Publication year - 2006
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20577
Subject(s) - medicine , carcinoembryonic antigen , colorectal cancer , ca19 9 , oncology , gastroenterology , oncofetal antigen , carcinoma , tumor marker , cancer , pancreatic cancer , tumor associated antigen , immunotherapy
Background and Objectives Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19‐9) are well known to be the most common tumor markers of colorectal carcinomas. However, the significance of increase in these markers to predict the prognosis of the patients remains a problem for debate. Methods One hundred three patients with colorectal carcinoma, who had been treated by resection and reconstruction of digestive tracts were studied. Correlation of preoperative serum value of CEA and CA19‐9 with clinicopathologic features including prognosis of the patients was investigated. Results Preoperative elevation of both of the two markers proved to be an independent prognostic indicator, however, an elevation of only one of the two markers did not obtain a prognostic significance. Conclusions Combined data of preoperative increase in CEA and CA19‐9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma. J. Surg. Oncol. 2006;94:132–137. © 2006 Wiley‐Liss, Inc.