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Primary and recurrent retroperitoneal soft tissue sarcoma: Prognostic factors affecting survival
Author(s) -
Chiappa Antonio,
Zbar Andrew P.,
Bertani Emilio,
Biffi Roberto,
Luca Fabrizio,
Crotti Cristiano,
Testori Alessandro,
Lazzaro Gianluca,
De Pas Tommaso,
Ugo Pace,
Andreoni Bruno
Publication year - 2006
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20446
Subject(s) - medicine , surgery , sarcoma , soft tissue sarcoma , soft tissue , overall survival , resection , primary tumor , survival rate , survival analysis , cancer , metastasis , pathology
Background and Objectives To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS). Methods Between July 1994 and January 2001, 34 patients (15M, 19F; mean age: 56years, range: 25–77) were evaluated. Complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. Results Twenty‐eight out of 34 patients (82%) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration. Twenty‐three patients had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 patients with a grossly complete resection having histologically involved resection margins). Twenty‐one out of 28 patients (75%) underwent removal of contiguous intra‐abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21%). High tumor grade results a significant variable for a worse survival in all 28 patients (100% 5 years survival for low grade vs. 0% for high grade; P = 0.0004). Amongst completely resected patients, only histologic grade and peroperative blood transfusions affected disease‐free survival ( P = 0.04 and P = 0.05, respectively). Conclusions An aggressive surgical approach in both primary and recurrent RPS is associated with long‐term survival. J. Surg. Oncol. 2006;93:456–463. © 2006 Wiley‐Liss, Inc.