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Novel molecular targeted therapy for esophageal cancer
Author(s) -
Schrump David S.,
Nguyen Dao M.
Publication year - 2005
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20367
Subject(s) - medicine , esophageal cancer , targeted therapy , cancer research , carcinogenesis , cancer , refractory (planetary science) , oncology , biology , astrobiology
Esophageal cancers are highly lethal neoplasms which are generally refractory to conventional multidisciplinary interventions. Recent elucidation of the mechanisms of esophageal carcinogenesis, as well as preclinical studies utilizing chromatin remodeling agents and inhibitors of oncogene signaling in conjunction with conventional chemotherapeutic agents provide new opportunities for the development of potentially efficacious molecular targeted therapies for these malignancies. J. Surg. Oncol. 2005;92:257–261. © 2005 Wiley‐Liss, Inc.