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Apoptotic and anti‐angiogenic strategies in liver and gastrointestinal malignancies
Author(s) -
Kountouras Jannis,
Zavos Christos,
Chatzopoulos Dimitrios
Publication year - 2005
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20254
Subject(s) - angiogenesis , medicine , cancer research , carcinogenesis , metastasis , apoptosis , suppressor , cancer , tumor suppressor gene , biology , genetics
Inappropriate suppression of apoptosis is strongly implicated in tumorigenesis. Tumor development is heralded by the mutation of tumor suppressor genes and overexpression of anti‐apoptotic genes permitting cell survival. Thus, inducing the apoptotic process in various ways can be applied to cancer management. Besides, angiogenesis is a crucial process for tumor growth and metastasis. New strategies targeting fundamental play‐markers of the angiogenic process are currently under investigation. J. Surg. Oncol. 2005;90:249–259. © 2005 Wiley‐Liss, Inc.