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Haemostatic alterations in colorectal cancer: Perspectives for future treatment
Author(s) -
Lykke Jakob,
Nielsen Hans Jørgen
Publication year - 2004
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20158
Subject(s) - medicine , colorectal cancer , angiogenesis , cancer , treatment modality , modalities , hemostasis , oncology , cancer research , social science , sociology
The role of the haemostatic system in colorectal cancer (CRC) is reviewed. Correlations between the activation of the haemostatic system and overall survival have been suggested. Experimental studies indicate that the haemostatic system plays a key role in growth, invasion and dissemination of tumour cells, and in tumour related angiogenesis. Additional activation by the surgical trauma and postoperative infections are discussed. Finally, anti‐cancer modalities directed against regulation of the haemostatic system in CRC are considered. J. Surg. Oncol. 2004;88:269–275. © 2004 Wiley‐Liss, Inc.