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High‐mobility group protein 1(Y): Metastasis‐associated or metastasis‐inducing?
Author(s) -
Evans Alice,
Lennard Thomas W.J.,
Davies Barry R.
Publication year - 2004
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20136
Subject(s) - medicine , metastasis , high mobility group , cancer metastasis , oncology , cancer , transcription factor , cancer research , gene , bioinformatics , genetics , biology
Metastasis is the major cause of mortality and morbidity for patients with cancer. The high‐mobility group protein 1(Y) [HMG‐1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG‐1(Y) in metastasis. J. Surg. Oncol. 2004;88:86–99. © 2004 Wiley‐Liss, Inc.