High‐mobility group protein 1(Y): Metastasis‐associated or metastasis‐inducing? | Zendy

Evans Alice | Zendy; Lennard Thomas W.J. | Zendy; Davies Barry R. | Zendy

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High‐mobility group protein 1(Y): Metastasis‐associated or metastasis‐inducing?

Author(s) -

Evans Alice,

Lennard Thomas W.J.,

Davies Barry R.

Publication year - 2004

Publication title -

journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.201

H-Index - 111

eISSN - 1096-9098

pISSN - 0022-4790

DOI - 10.1002/jso.20136

Subject(s) - medicine , metastasis , high mobility group , cancer metastasis , oncology , cancer , transcription factor , cancer research , gene , bioinformatics , genetics , biology

Metastasis is the major cause of mortality and morbidity for patients with cancer. The high‐mobility group protein 1(Y) [HMG‐1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG‐1(Y) in metastasis. J. Surg. Oncol. 2004;88:86–99. © 2004 Wiley‐Liss, Inc.

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