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Vascular endothelial growth factor in esophageal cancer
Author(s) -
Kleespies Axel,
Guba Markus,
Jauch KarlWalter,
Bruns Christiane J.
Publication year - 2004
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20070
Subject(s) - medicine , angiogenesis , vascular endothelial growth factor , dysplasia , esophagus , adenocarcinoma , esophageal cancer , microvessel , oncology , vegf receptors , neovascularization , radiation therapy , vascular endothelial growth factor c , cancer , cancer research , pathology , vascular endothelial growth factor a
Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis of many solid malignancies. The influence of angiogenesis and VEGF expression on progression and recurrence of esophageal cancer has been investigated over the last years. This article reviews the prognostic significance of VEGF expression, microvessel density (MVD), and lymphangiogenic factors in squamous cell carcinoma (SCC), Barrett's dysplasia, and adenocarcinoma (AC) of the esophagus, their predictive value for treatment response to chemo‐radiotherapy and new anti‐angiogenic treatment strategies. J. Surg. Oncol. 2004;87:95–104. © 2004 Wiley‐Liss, Inc.