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Margins in extra‐abdominal desmoid tumors: A comparative analysis
Author(s) -
Leithner Andreas,
Gapp Markus,
Leithner Katharina,
Radl Roman,
Krippl Peter,
Beham Alfred,
Windhager Reinhard
Publication year - 2004
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20057
Subject(s) - medicine , surgical margin , margin (machine learning) , surgical excision , surgery , radiology , resection , machine learning , computer science
Background and Objectives The main treatment of extra‐abdominal desmoid tumors remains surgery, but recurrence rates up to 80% are reported. The impact of microscopic surgical margin status according to the Enneking classification system is discussed controversially. Methods Therefore, the authors screened the published literature for reliable data on the importance of a wide or radical excision of extra‐abdominal desmoid tumors. All studies with more than ten patients, a surgical treatment only, and margin status stated were included. Results Only 12 out of 49 identified studies fulfilled the inclusion criteria. One hundred fifty‐two primary tumors were excised with wide or radical microscopic surgical margins, while in 260 cases a marginal or intralesional excision was performed. In the first group 41 patients (27%) and in the second one 187 patients (72%) developed a recurrence. Therefore, microscopic surgical margin status according to the Enneking classification system is a significant prognostic factor ( P < 0.001). Conclusions The data of this review underline the strategy of a wide or radical local excision as the treatment of choice. Furthermore, as a large number of studies had to be excluded from this analysis, exact microscopic surgical margin status should be provided in future studies in order to allow comparability. J. Surg. Oncol. 2004;86:152–156. © 2004 Wiley‐Liss, Inc.