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Pathologic analysis of sentinel lymph nodes in melanoma patients: Current and future trends
Author(s) -
Roberts Alice A.,
Cochran Alistair J.
Publication year - 2004
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.20028
Subject(s) - medicine , melanoma , sentinel lymph node , breast cancer , sentinel node , dissection (medical) , lymph node , radiology , axillary lymph node dissection , cancer , oncology , surgery , cancer research
Sentinel lymph node dissection (SLND) has become the standard of care for the staging of clinically‐node negative melanomas and breast cancers. A large literature documents the efficacy of SLND in the staging of melanoma and breast cancer. The SLND has lower associated patient morbidity in comparison to elective node dissections that remove the closest regional‐draining node group. SLND has improved accuracy over traditional regional node dissection for the staging of melanoma. Currently, several multicenter trials are evaluating the prognostic significance of melanoma micrometastases in SLN detected by immunohistochemical and molecular methods. Pending trial outcome analysis, SLND has no proven effect on mortality. However, given the current oncologic emphasis on detection and removal of nodal tumor metastases, the technique has an important role in minimizing the invasiveness of tumor staging for melanoma and breast cancer. As long as lymph node metastases are used for staging solid malignancies, surgical pathologists are likely to encounter SLN excisional biopsies as a part of their routine practice. J. Surg. Oncol. 2004;85:152–161. © 2004 Wiley‐Liss, Inc.