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Multidrug resistance gene (MDR‐1) expression as a useful prognostic factor in patients with human hepatocellular carcinoma after surgical resection
Author(s) -
Kato Atsushi,
Miyazaki Masaru,
Ambiru Satoshi,
Yoshitomi Hideyuki,
Ito Hiroshi,
Nakagawa Koji,
Shimizu Hiroaki,
Yokosuka Osamu,
Nakajima Nobuyuki
Publication year - 2001
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.1129
Subject(s) - hepatocellular carcinoma , medicine , multiple drug resistance , stage (stratigraphy) , multivariate analysis , oncology , carcinoma , survival analysis , gastroenterology , clinical significance , pathology , drug resistance , biology , paleontology , microbiology and biotechnology
Background: Multidrug resistance gene (MDR‐1) overexpression has been correlated with tumor aggressiveness and worse prognosis in some human neoplasms. The aim of this study is to evaluate the clinical value of MDR‐1 mRNA expression as a prognostic factor after surgical resection in human hepatocellular carcinoma (HCC). Methods: MDR‐1 mRNA levels in tissue samples from 34 patients with HCC, who underwent surgical resection, were measured by quantitative northern blot analysis. We stratified these patients into two groups according to a ratio of MDR‐1 mRNA levels of HCC to nontumorous tissue; MDR‐1 mRNA ratio ≥ 1.0 and < 1.0. The overall and disease‐free survival rates were analyzed using multivariateregression analysis. Results: The median survival periods were 10.3 and 35.8 months for patients with the MDR‐1 mRNA ratio ≥ 1.0 and < 1.0, respectively, and the corresponding 5‐year survival rates were 33 and 54%, respectively, P < 0.05. The multivariate analysis revealed that TNM stage and MDR‐1 mRNA ratio were independent factors for predicting overall survival after surgical resection. Conclusion: This study suggested that the measurement of the MDR‐1 mRNA levels in HCC and nontumorous liver tissue might be a useful prognostic factor after surgical resection in patients with HCC. J. Surg. Oncol. 2001;78:110–115. © 2001 Wiley‐Liss, Inc.