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Cell proliferative activity and expression of cell‐cell adhesion factors (E‐cadherin, α‐, β‐, and γ‐catenin, and p120) in sarcomatoid renal cell carcinoma
Author(s) -
Kuroiwa Kentaro,
Konomoto Tatsuo,
Kumazawa Joichi,
Naito Seiji,
Tsuneyoshi Masazumi
Publication year - 2001
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.1082
Subject(s) - pathology , immunostaining , immunohistochemistry , medicine , cadherin , renal cell carcinoma , cell , catenin , cell adhesion molecule , carcinoma , biology , immunology , wnt signaling pathway , signal transduction , genetics , biochemistry
Background and Objectives Sarcomatoid RCC (renal cell carcinoma) is an uncommon, but not rare, neoplasm which has been shown to have a much worse prognosis than common RCC. The current study was designed to investigate the association of proliferative activity and cell‐cell adhesion molecules with sarcomatoid RCC. Methods Proliferative activity (Ki‐67 labeling index) and expression of cell‐cell adhesion associated molecules (E‐cadherin, α‐, β‐, and γ‐catenin, and p120) were examined using immunohistochemical techniques in 11 cases of sarcomatoid RCC. Results In six patients with sarcomatous component more than 50%, five were died within 24 month after diagnosis. The expression of these molecules within the carcinomatous and sarcomatous components of sarcomatoid RCC was compared. The mean Ki‐67 labeling index in the sarcomatous components (12.6%) is statistically higher than in the carcinomatous components (3.7%) ( P < 0.05). The expressions of E‐cadherin, and α‐, β‐, and γ‐catenin were statistically decreased in the sarcomatous components compared to the carcinomatous components. However, no differences were observed regarding p120 immunostaining. Conclusions The findings of the current study suggest that the range of the sarcomatous component may be a prognostic factor in RCC, and the malignant behavior of sarcomatoid RCC is due to high cell proliferative activity and decreased expressions of E‐cadherin and α‐, β‐, and γ‐catenin in the sarcomatous component. J. Surg. Oncol. 2001; 77:123–131. © 2001 Wiley‐Liss, Inc.