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Prognostic value of intratumoral CD8 + T lymphocyte in extrahepatic bile duct carcinoma as essential immune response
Author(s) -
Oshikiri Taro,
Miyamoto Masaki,
Shichinohe Toshiaki,
Suzuoki Masato,
Hiraoka Kei,
Nakakubo Yoshihiro,
Shinohara Toshiya,
Itoh Tomoo,
Kondo Satoshi,
Katoh Hiroyuki
Publication year - 2003
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.10321
Subject(s) - cd8 , perineural invasion , medicine , pathology , immune system , carcinoma , cytotoxic t cell , infiltration (hvac) , lymph node , bile duct , t lymphocyte , lymph , cancer , biology , immunology , biochemistry , physics , in vitro , thermodynamics
Background and Objectives Tumor‐infiltrating lymphocytes form an important aspect of the host defense against an expanding neoplasm. CD8 + T cells have been identified as a prognostic factor in several cancers. Here, we investigate that the influence of CD8 + T cells on extrahepatic bile duct carcinoma (EBDC) patient survival. Methods CD8 + T cell immunoreactivity in 58 surgically resected EBDC specimens was investigated. The relationship between CD8 + T cell immunoreactivity and clinical and histopathologic features was analyzed. Results Thirty‐two tumors (55%) possessed intratumoral CD8 + T cells. The degree of intratumoral CD8 + T cell immunoreactivity demonstrated a significant relationship to lower numbers of lymph node metastasis, reduced venous invasion, decreased perineural invasion, and better pTNM staging. Intratumoral CD8 + T cells were also associated with increased patient survival. Multivariate analysis indicated that the presence of intratumoral CD8 + T cells was an independent prognostic factors. Conclusions The infiltration of a cancer cell nest by CD8 + T cells is a reliable marker predicting increased survival of patients with EBDC. J. Surg. Oncol. 2003;84:224–228. © 2003 Wiley‐Liss, Inc.