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The evolution of lung cancer screening
Author(s) -
Wilkinson Neal W.,
Loewen Gregory M.,
Klippenstein Donald L.,
Litwin Alan M.,
Anderson Timothy M.
Publication year - 2003
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.10315
Subject(s) - medicine , lung cancer , sputum , lung cancer screening , lung , cancer , cytology , stage (stratigraphy) , oncology , pathology , tuberculosis , paleontology , biology
In the 1970s, four trials failed to demonstrate any mortality reduction using a combination of chest X‐ray (CXR) and/or sputum cytology. The recent early lung cancer action project (ELCAP) demonstrated that modern screening is capable of detecting Stage I lung cancers. Bronchial epithelial changes leading up to cancers are now being understood to include histologic changes and genetic alterations. Emerging molecular markers detected in sputum and serum show promise in the future of lung cancer screening. J. Surg. Oncol. 2003;84:234–238. © 2003 Wiley‐Liss, Inc.