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Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine‐18‐labeled fluoro‐deoxyglucose (FDG‐PET)
Author(s) -
Koh Toshimori,
Taniguchi Hiroki,
Yamaguchi Akihiro,
Kunishima Satoshi,
Yamagishi Hisakazu
Publication year - 2003
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.10295
Subject(s) - medicine , positron emission tomography , gallbladder , malignancy , deoxyglucose , differential diagnosis , radiology , gallbladder cancer , nuclear medicine , cholecystitis , lesion , pathology
Abstract Background and Objectives The purpose of this paper is to evaluate the utility of positron emission tomography (PET) with fluorine‐18‐labeled fluoro‐deoxyglucose (FDG) in the preoperative differential diagnosis of gallbladder tumors. We performed PET studies of gallbladder tumors in order to predict the malignancy of these tumors preoperatively. Methods Sixteen patients who had protuberant lesions in the gallbladder and who were scheduled to undergo surgery were studied with PET using FDG. Focally increased FDG uptake in the gallbladder region was considered malignant. The FDG‐PET findings were compared with the histological findings of surgical pathology. Results Sensitivity of FDG‐PET was 75% (6/8 patients). One of two false‐negative cases suffered from diabetes mellitus, and in the other case, the lesion was small. Specificity was 87.5% (7/8 patients). A case with xanthogranulomatous cholecystitis (XGC) was the only false‐positive case. Conclusions FDG‐PET may be able to provide important information for evaluating the malignancy of gallbladder tumors. J. Surg. Oncol. 2003;84:74–81. © 2003 Wiley‐Liss, Inc.