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Clinicopathological characteristics of superficial spreading type early gastric cancer
Author(s) -
Imai Masato,
Kondo Yukifumi,
Osawa Shohei,
Nishida Yasunori,
Okada Kuniaki,
Ishizu Hiroyuki,
Masuko Hiroyuki,
Hata Tsunetake,
Uemura Kazuhito,
Kina Masaya,
Honda Shohei,
Ishiyama Gentaro,
Takahashi Toru,
Hino Atsushi
Publication year - 2003
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.10229
Subject(s) - medicine , cancer , pathological , surgical margin , lymphovascular invasion , lymph node , lymphatic system , dissection (medical) , pathology , lymph , signet ring cell , metastasis , radiology , adenocarcinoma
Background and Objectives Superficial spreading type early gastric cancer is characterized by its atypical growth pattern and occasionally indistinct tumor margin. Because it is a rare form of early gastric cancer, the clinicopathological details are not apparent. The aim of this study was to clarify the clinicopathological features of the superficial spreading type of early gastric cancer. Methods A retrospective study was conducted in 1,062 surgically resected patients with early gastric cancer. Hospital records were compared between patients with superficial spreading type early gastric cancer and those with more common types of early gastric cancer. Results Sixty‐nine patients (6.9%) had superficial spreading lesions. The male to female ratio was 1.2:1. The most frequent histological type was signet‐ring cell carcinoma (32%). The distinguishing histopathological features were submucosal invasion (67%), lymphatic invasion (32%), and lymph node metastasis (30%). There were discrepancies in tumor area between surgical findings and pathological diagnosis in 24 patients (35%) with superficial spreading type. More extensive lymph node dissection was performed and all patients survived in the group with superficial spreading lesions. Conclusions The most appropriate treatment for the superficial spreading type of early gastric cancer is wide surgical resection with extensive lymph node dissection. J. Surg. Oncol. 2003;83:94–98. © 2003 Wiley‐Liss, Inc.