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Prognostic significance of p27 KIP1 expression in resected non–small cell lung cancers: Analysis in combination with expressions of p16 INK4A , pRB, and p53
Author(s) -
Hirabayashi Hirohisa,
Ohta Mitsunori,
Tanaka Hisaichi,
Sakaguchi Masahiro,
Fujii Yoshitaka,
Miyoshi Shinichiro,
Matsuda Hikaru
Publication year - 2002
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.10176
Subject(s) - immunohistochemistry , medicine , univariate analysis , proportional hazards model , pathological , suppressor , cancer research , cell , survival analysis , lung , stage (stratigraphy) , cell cycle , pathology , oncology , cancer , multivariate analysis , biology , paleontology , genetics
Background and Objectives Whether a prognostic role for expression of the tumor suppressor gene (TSG) products exists in resected non–small call lung cancers (NSCLCs) remains controversial. Our study was performed to determine the value of TSGs expressions for patients survival in NSCLCs. Methods We examined 108 resected NSCLCs for the expression of TSG products, p27 KIP1 , p16 INK4A , pRB, and p53 that govern cell cycle transition by immunohistochemistry and compared them with patient clinical characteristics and prognoses. Results Abnormal expressions of p27 KIP1 , p16 INK4A , pRB, and p53 were found in 61 (57%), 53 (49%), 42 (39%), and 48 (44%), respectively, of the 108 NSCLCs. Univariate analysis showed abnormal expression of p27 KIP1 to be a strong indicator for poor patient survival, not only in the total cohort ( P = 0.0024), but also in subgroups with T1–T2 ( P = 0.016), N0 ( P = 0.047), and squamous cell carcinomas ( P = 0.026), but not according to the expression of p16 INK4A , pRB, or p53. In the Cox regression analysis, p27 KIP1 expression was found to be an independent prognostic factor ( P = 0.0148) and associated with pathological stage ( P = 0.0278). Conclusions Our results suggest that abnormal p27 KIP1 expression may be a useful indicator to predict postoperative prognosis, especially in patients with early stage NSCLCs, as compared to other TSG products examined. J. Surg. Oncol. 2002;81:177–184. © 2002 Wiley‐Liss, Inc.