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Predictive value of dihydropyrimidine dehydrogenase expression in tumor tissue, regarding the efficacy of postoperatively administered UFT (Tegafur + Uracil) in patients with p‐stage I nonsmall‐cell lung cancer
Author(s) -
Nakagawa Tatsuo,
Tanaka Fumihiro,
Takata Tetsuya,
Matsuoka Katsunari,
Miyahara Ryo,
Otake Yosuke,
Yanagihara Kazuhiro,
Fukushimab Masakazu,
Wada Hiromi
Publication year - 2002
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.10137
Subject(s) - dihydropyrimidine dehydrogenase , tegafur , medicine , stage (stratigraphy) , adjuvant , oncology , lung cancer , fluorouracil , chemotherapy , uracil , adjuvant therapy , immunohistochemistry , gastroenterology , thymidylate synthase , dna , paleontology , genetics , biology
Background and Objectives Dihydropyrimidine dehydrogenase (DPD) activity in tumor cells has been suggested to be one of the factors determining the effectiveness of 5‐fluorouracil (5‐FU). In the present study, we analyzed DPD expression in tumors and investigated retrospectively the relationship between the efficacy of UFT (Tegafur + Uracil) as adjuvant chemotherapy and DPD expression in nonsmall‐cell lung cancer (NSCLC). Methods DPD expression of 166 resected p‐stage I NSCLC was examined immunohistochemically. Patients who were administered UFT alone as adjuvant therapy comprised the UFT group (n = 54), and those who underwent only surgery comprised the control group (n = 112). DPD expression was categorized as either high or low, according to intensity of staining. Results DPD expression was high in 98 patients (59.0%) and low in 68 patients (41.0%). Patients with low‐DPD tumors who were administered UFT had a significantly better prognosis than those who did not receive adjuvant treatment ( P = 0.021). No significant difference was found between the two groups of patients with high‐DPD tumors ( P = 0.598). Conclusions DPD expression may predict the efficacy of UFT after surgery for p‐stage I NSCLC. A prospective study is needed to confirm the role of DPD expression as a predictor of UFT efficacy. J. Surg. Oncol. 2002;81:87–92. © 2002 Wiley‐Liss, Inc.