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Silkworm dropping extract regulates food allergy symptoms via inhibition of Th2‐related responses in an ovalbumin‐induced food allergy model
Author(s) -
Jung Sun Young,
See HyeJoeng,
Kwon DaAe,
Choi DaeWoon,
Lee SoYoung,
Shon DongHwa,
Shin Hee Soon
Publication year - 2019
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.9993
Subject(s) - ovalbumin , immunoglobulin e , allergy , food allergy , immunology , medicine , degranulation , antibody , immune system , receptor
BACKGROUND Silkworm droppings have long been used in traditional medicine to remedy allergic itching, palsy, blood circulation problems, and arthritis in Asian countries. To investigate the anti‐allergic effect of silkworm dropping extract (SDE) and its mechanism, we used a mouse model of food allergy induced by ovalbumin (OVA). RESULTS SDE ameliorated the symptoms of OVA‐induced food allergies, and the levels of T helper 2 (Th2)‐related cytokines [such as interleukin (IL)‐4, IL‐5, IL‐10, and IL‐13] were found to be significantly decreased in both the spleen and mesenteric lymph nodes by SDE. Furthermore, SDE treatment directly inhibited OVA permeation, IL‐4 production, and degranulation of mast cells; in contrast, immunoglobulin E (IgE) production from B cells was not affected. CONCLUSION These results suggest that SDE has potential anti‐allergic activities, and SDE may be useful in the treatment/prevention of allergic disorders such as food allergies, serving as therapeutic agents. © 2019 Society of Chemical Industry