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A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high‐fat diet‐induced obesity mouse model
Author(s) -
Cheng Lu,
Chen Yuhui,
Zhang Xin,
Zheng Xiaojie,
Cao Jinxuan,
Wu Zufang,
Qin Wenyan,
Cheng Kejun
Publication year - 2019
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.9622
Subject(s) - firmicutes , prebiotic , metagenomics , gut flora , bacteroidetes , microbiome , biology , kegg , dysbiosis , obesity , bioavailability , biochemistry , gene , pharmacology , endocrinology , genetics , transcriptome , gene expression , 16s ribosomal rna
BACKGROUND As a result of a low bioavailability, the majority of Cyclocarya paliurus flavonoids (CPF) remain in the large intestine where they accumulate to exert a modulatory effect on the intestinal micro‐ecology. Therefore, the present study investigated the modulatory effect of CPF on intestinal microbiota. RESULTS CPF dramatically ameliorated the obesity‐induced gut dysbiosis. A significant decrease ( P < 0.05) was observed in the ratio of Firmicutes / Bacteroidetes after CPF treatment for 8 weeks. Moreover, Kyoto Encyclopedia of Genes and Genomes pathways of biosynthesis of amino acids, the two‐component system and ATP‐binding cassette transporters enriched the most differentially expressed genes after CPF intervention. CONCLUSION The results of the present study indicate that CPF might have prebiotic‐like activity and could be used as a functional food component with potential therapeutic utility to prevent obesity‐related metabolic disorders by manipulating the gut flora and affecting certain metabolic pathways, thus contributing to the improvement of human health. © 2019 Society of Chemical Industry