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Antihyperglycemic activities of twig extract of indigenous cinnamon ( Cinnamomum osmophloeum ) on high‐fat diet and streptozotocin‐induced hyperglycemic rats
Author(s) -
Lin GongMin,
Hsu ChiaYun,
Chang ShangTzen
Publication year - 2018
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.9286
Subject(s) - cinnamomum , streptozotocin , twig , weight gain , amylase , hyperlipidemia , traditional medicine , chemistry , medicine , body weight , endocrinology , diabetes mellitus , biochemistry , enzyme , alternative medicine , pathology , traditional chinese medicine , cassia
Abstract BACKGROUND Cinnamomum osmophloeum (indigenous cinnamon) is an endemic species in Taiwan and its twigs contain abundant A‐type proanthocyanidins. C. osmophloeum twig extracts (CoTEs) were found to have α ‐glucosidase and α ‐amylase inhibitory activities in vitro . The aim of this study is to further investigate the antihyperglycemic activity of CoTEs in hyperglycemic rats. RESULTS Hyperglycemic rats were divided into three groups and were treated orally with high‐dosage CoTEs (HCO, 150 mg kg −1 ), low‐dosage CoTEs (LCO, 30 mg kg −1 ) and positive control (PC, 30 mg kg −1 pioglitazone). The HCO group showed improved glucose tolerance in an oral glucose tolerance test after 1 month of treatment, contributed by the inhibition of intestinal disaccharidases, amylase, and lipase. Compared with the PC group, both the HCO and LCO groups had decreased weight of visceral fats and lower atherogenic index; while their low‐density lipoprotein‐cholesterol, food intake, feed efficiency, and biochemical parameters remained unchanged compared with the NC group. Furthermore, the HCO group had decreased weight gain and the LCO group had decreased serum leptin level. CONCLUSION These results suggest that CoTE has potential antihyperglycemic activities for treating hyperglycemia without weight gain. © 2018 Society of Chemical Industry