Premium
Immunotoxicity of aflatoxin M 1 : as a potent suppressor of innate and acquired immune systems in a subacute study
Author(s) -
Shirani Kobra,
Zanjani Bamdad R,
Mahmoudi Mahmoud,
Jafarian Amir H,
Hassani Faezeh V,
Giesy John P,
Karimi Gholamreza
Publication year - 2018
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.9240
Subject(s) - innate immune system , spleen , immunology , immune system , antibody , immunity , aflatoxin , in vivo , in vitro , titer , hemagglutination , biology , chemistry , biochemistry , food science , microbiology and biotechnology
BACKGROUND Although, to date, there have been several in vitro and in vivo studies of immunomodulatory effects of aflatoxin M 1 (AFB 1 ), little is known about the effect of AFM 1 on various aspects of innate and acquired immunity. In the present study, AFM 1 was administered intraperitoneally, at doses of 25 and 50 μg kg −1 , body mass for 28 days and various immunological parameters were measured. RESULTS Several parameters related to immune function were suppressed: organ mass, cellularity of spleen, proliferation response to lipopolysaccaride and phytohemagglutinin‐A, hemagglutination titer, delayed type of hypersensitivity response, spleen cell subtypes, serum hemolytic activity, serum immunoglobulin G level and cytokine production. AFM 1 did not cause changes in body mass, hematological parameters or the concentration of immunoglobulin M in blood serum. Conclusions Overall, the data suggested that AFM 1 suppressed innate and acquired immunity. Therefore, with respect to consumer safety, it is extremely important to further control the level of AFM 1 in milk, and this should be considered as a precedence for risk management actions. © 2018 Society of Chemical Industry