Premium
Cordyceps cicadae mycelia and its active compound HEA exert beneficial effects on blood glucose in type 2 diabetic db/db mice
Author(s) -
Li IChen,
Lin Shan,
Tsai YuehTing,
Hsu JuiHsia,
Chen YenLien,
Lin WenHsin,
Chen ChinChu
Publication year - 2018
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.9221
Subject(s) - mycelium , pharmacology , type 2 diabetes , diabetes mellitus , cordyceps , medicine , biology , endocrinology , traditional medicine , botany
BACKGROUND This is the first study to investigate the therapeutic effects of Cordyceps cicadae ( C. cicadae) mycelia and its active compound N 6 ‐(2‐hydroxyethyl)adenosine (HEA) on blood glucose in genetically diabetic mice. RESULTS Forty mice, 9 weeks of age, were divided into normal control, diabetic control, and three C. cicadae mycelia treated diabetic groups. After 9 weeks of continuous supplementation, the oral glucose tolerance test (OGTT) and homeostasis model of assessment‐insulin resistance index showed significant glucose tolerance with C. cicadae mycelia. Furthermore, the effect of HEA is similar to that of C. cicadae mycelia in an OGTT, suggesting that HEA could be the major factor responsible for the functional properties of C. cicadae mycelia. CONCLUSION Based on these findings, it is suggested that the therapeutic effect of C. cicadae mycelia may be driven by one of its active components, HEA, which could alleviate many diabetes complications in genetically obese mice and may offer promise as a supplement for diabetes management. © 2018 Society of Chemical Industry