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The protective effects of Sauropus spatulifolius on acute lung injury induced by lipopolysaccharide
Author(s) -
Wei Xiaochen,
Li Yanmei,
Li Meng,
Min Chunyan,
Lu Hui,
Li Qirun,
Yuan Jie,
Chen Chen,
Li Heran,
Zhang Jian
Publication year - 2018
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.8964
Subject(s) - antioxidant , superoxide dismutase , catalase , lipopolysaccharide , myeloperoxidase , chemistry , in vitro , tumor necrosis factor alpha , food science , pharmacology , traditional medicine , medicine , biochemistry , immunology , inflammation
BACKGROUND Sauropus spatulifolius Beille (named ‘Long‐Li‐Ye’ in China) is used to make ‘herbal tea’ to prevent pneumonia. This study aimed to evaluate the antioxidant activities in vitro and the protective effects of Long‐Li‐Ye on acute lung injury (ALI) induced by lipopolysaccharide (LPS). RESULTS The supernatant after ethanol addition to Long‐Li‐Ye water extract (LLYCSL) and the resin eluting fraction of LLYCSL (LLY40) showed strong antioxidant activities in vitro . LLYCSL and LLY40 could attenuate ALI via decreasing myeloperoxidase activity, increasing superoxide dismutase activity and decreasing the levels of tumor necrosis factor α (TNF‐α), interleukin 1 β (IL‐1β) and IL‐6. In addition, LLY40 could increase catalase activity, increase the levels of IL‐10, IL‐4 and IL‐13 and decrease the TNF‐ α /IL‐10 ratio. CONCLUSION Long‐Li‐Ye could be used as a natural antioxidant for food production and functional food or dietary supplementation for people with ALI. © 2018 Society of Chemical Industry