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Rare sugars, d ‐allulose, d ‐tagatose and d ‐sorbose, differently modulate lipid metabolism in rats
Author(s) -
Nagata Yasuo,
Mizuta Narumi,
Kanasaki Akane,
Tanaka Kazunari
Publication year - 2017
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.8687
Subject(s) - chemistry , lipid metabolism , biochemistry , metabolism , food science
BACKGROUND Rare sugars including d ‐allulose, d ‐tagatose, and d ‐sorbose are present in limited quantities in nature; some of these rare sugars are now commercially produced using microbial enzymes. Apart from the anti‐obesity and anti‐hyperglycaemic activities of d ‐allulose, effects of these sugars on lipid metabolism have not been investigated. Therefore, we aimed to determine if and how d ‐tagatose and d ‐sorbose modulate lipid metabolism in rats. After feeding these rare sugars to rats, parameters on lipid metabolism were determined. RESULTS No diet‐related effects were observed on body weight and food intake. Hepatic lipogenic enzyme activity was lowered by d ‐allulose and d ‐sorbose but increased by d ‐tagatose. Faecal fatty acid excretion was non‐significantly decreased by d ‐allulose, but significantly increased by d ‐sorbose without affecting faecal steroid excretion. A trend toward reduced adipose tissue weight was observed in groups fed rare sugars. Serum adiponectin levels were decreased by d ‐sorbose relative to the control. Gene expression of cholesterol metabolism‐related liver proteins tended to be down‐regulated by d ‐allulose and d ‐sorbose but not by d ‐tagatose. In the small intestine, SR‐B1 mRNA expression was suppressed by d ‐sorbose. CONCLUSION Lipid metabolism in rats varies with rare sugars. Application of rare sugars to functional foods for healthy body weight maintenance requires further studies. © 2017 Society of Chemical Industry