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Changes in composition and content of food‐derived peptide in human blood after daily ingestion of collagen hydrolysate for 4 weeks
Author(s) -
Shigemura Yasutaka,
Suzuki Asahi,
Kurokawa Mihoko,
Sato Yoshio,
Sato Kenji
Publication year - 2017
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.8677
Subject(s) - ingestion , hydrolysate , hydroxyproline , chemistry , peptide , medicine , endocrinology , food science , biochemistry , biology , hydrolysis
BACKGROUND Daily ingestion of collagen hydrolysate for a long period improves skin and joint conditions. It has been speculated that the beneficial effects are exerted by food‐derived hydroxyproline (Hyp) peptides, which are detected in human blood after single ingestions. In the present study, to investigate the effect of long‐term ingestion of collagen hydrolysate on Hyp peptides profile in blood, the concentrations of Hyp‐peptides in human blood before and after daily ingestion for a long period were examined. RESULTS Hyp‐peptides increased to a maximum level at 1 h after ingestion and reverted to their initial levels within 24 h during experimental period. Pro‐Gly and Hyp‐peptides such as Pro‐Hyp‐Gly, Pro‐Hyp, Ile‐Hyp, Leu‐Hyp, Hyp‐Gly, Glu‐Hyp and Ala‐Hyp were identified in the blood after ingestion of collagen hydrolysate at 4.5 g day −1 for 4 weeks. For the whole period, Pro‐Hyp was the leading compound. The compositional rate of Hyp‐Gly showed a tendency to increase, while that of Pro‐Hyp tended to decrease after daily ingestion. CONCLUSION The present results indicate that daily ingestion of collagen hydrolysate for a long period can change compositional rate of Hyp peptides in human blood. This fact suggests that long‐term ingestion of collagen hydrolysate might change exo‐ or endo‐type protease activity in the digestive tract, which may consequently promote beneficial effects. © 2017 Society of Chemical Industry