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Beneficial effects of lipidic extracts of saladette tomato pomace and Serenoa repens on prostate and bladder health in obese male Wistar rats
Author(s) -
EspinosaJuárez Josué V,
ColadoVelázquez Juventino III,
MaillouxSalinas Patrick,
MedinaContreras JML,
CorreaLópez P Valentín,
GómezViquez Norma L,
MezaCuenca Fabián,
Huang Fengyang,
Bravo Guadalupe
Publication year - 2017
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.8308
Subject(s) - hyperplasia , prostate , contractility , endocrinology , medicine , muscle hypertrophy , lower urinary tract symptoms , urology , cancer
BACKGROUND Obesity is associated with increased risk of a number of serious medical conditions, including urological disorders. This study investigated the effect of lipidic extracts of saladette tomato pomace ( STP ) and Serenoa repens ( SR ) on the prostate and bladder in a rat obese model induced by high‐carbohydrate diet. RESULTS High‐sucrose‐fed rats showed higher prostate weight as well as increased contractility and stromal and epithelial hyperplasia in the prostate. Treatment with STP and SR improved contractility and diminished hyperplasia and hypertrophy in the prostate. Obese animals also showed impaired bladder contractility, but neither extract reversed this deterioration. In the histological study, a disarray in the process of smooth muscle cell proliferation with non‐parallel fibers was observed; interestingly, treatment with STP and SR led to improvement in this derangement. CONCLUSION These findings indicated impaired contractility and hyperplasia in the prostate and bladder of obese rats induced by high sucrose. STP and SR could enhance prostate function by reducing contractility and hyperplasia and improve smooth muscle fiber structure and decrease cell proliferation in the bladder, suggesting their possible health‐beneficial effects on lower urinary tract symptoms. © 2017 Society of Chemical Industry