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Effect of a polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae ( LipiGo ®) in body weight loss: randomised, double‐blind, placebo‐controlled clinical trial in overweight and obese adults
Author(s) -
Santas Jonathan,
Lázaro Elisabet,
Cuñé Jordi
Publication year - 2017
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.8301
Subject(s) - placebo , overweight , waist , medicine , body mass index , weight loss , hydrolysate , obesity , randomized controlled trial , zoology , endocrinology , biochemistry , chemistry , biology , hydrolysis , alternative medicine , pathology
BACKGROUND In the present study we evaluated the weight loss effect of a polysaccharide‐rich food supplement, LipiGo ®, comprising a specific β ‐glucan–chitin–chitosan fraction ( BGCC ) obtained from the chemical hydrolysis of Saccharomyces cerevisiae , resulting as a by‐product of the brewing process. RESULTS A randomised, double‐blind, placebo‐controlled clinical trial was performed enrolling 56 overweight and obese subjects (body mass index, BMI , 25–35 kg m −2 ) who were not following any specific diet, and were given placebo or BGCC (3 g d −1 ) for 12 weeks. Results were analysed by intention‐to‐treat ( ITT ) and per‐protocol ( PP ) methods. Body weight increased in the placebo group compared to baseline ( ITT : 1.0 kg, P < 0.001; PP : 1.5 kg, P = 0.003), while it was slightly lowered in the BGCC group ( ITT : −0.8 kg, P = 0.210; PP : −1.1 kg, P = 0.182). BGCC , but not the consumption of placebo, also resulted in a reduction of waist circumference and body fat compared to baseline. CONCLUSIONS Results suggest that daily supplementation of BGCC may be useful for improving body weight and waist circumference in overweight and obese subjects, without relevant adverse effects. © 2017 Society of Chemical Industry