Premium
Assessing the effect of 5‐hydroxymethylfurfural on selected components of immune responses in mice immunised with ovalbumin
Author(s) -
Alizadeh Mohammad,
Khodaei Hamed,
Mesgari Abbasi Mehran,
SalehGhadimi Sevda
Publication year - 2017
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.8261
Subject(s) - ovalbumin , immunoglobulin e , immune system , immunology , antibody , maillard reaction , chemistry , interleukin 4 , allergic response , biology , biochemistry
BACKGROUND 5‐Hydroxymethylfurfural (5‐ HMF ) is one of the most important products of the Maillard reaction. In recent years, many profitable biological effects of this compound have been demonstrated. This study sought to elucidate the anti‐allergic effect of 5‐ HMF by investigating some selected components of the immune response in BALB /c mice immunised with ovalbumin ( OVA ). RESULTS Immunised animals had an increased level of serum total and OVA ‐specific antibodies when compared to the control ( P < 0.01).We found that the OVA ‐induced increase in serum IgE and OVA ‐specific IgE were significantly suppressed in the groups treated with 5‐ HMF ( P < 0.05). Moreover, interleukin‐4 ( IL ‐4) and interferon gamma ( IFN ‐γ) were significantly reduced in a dose‐independent manner when compared to the sensitised group ( P < 0.05). CONCLUSION 5‐ HMF inhibited the up‐regulation of total and OVA ‐specific IgE through the suppression of the Th2‐type immune response in immunised BALB /c mice. 5‐ HMF could therefore be a novel therapeutic approach for the prevention of IgE ‐mediated allergic diseases. © 2017 Society of Chemical Industry