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Impact of a novel synbiotic supplementation during gestation and lactation on immune responses in the Swiss albino mice offspring
Author(s) -
Nallagatla Himaja,
Hemalatha Rajkumar,
Kondapalli Narendra Babu,
Mohammed Shujauddin
Publication year - 2017
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.8059
Subject(s) - biology , lactation , offspring , prebiotic , immune system , immunity , lactobacillus rhamnosus , weaning , probiotic , immunology , gestation , immunostimulant , pregnancy , endocrinology , food science , genetics , bacteria
BACKGROUND Prebiotics from various regularly consumed cereals and novel substrates are currently being utilised as functional foods. The aim of this study was to determine the effect of synbiotic, formulated with prebiotic extracted from natural resources like green gram ( Vigna radiata ) along with probiotic Lactobacillus rhamnosus GG ( LGG ) in modulating immune responses in the offspring when supplemented during gestation and lactation. RESULTS Synbiotic supplementation was effective in improving cell mediated immunity and humoral immunity among F0 dams. Among F1 pups ( F1 Syn + and F1 Syn−), synbiotic supplementation showed significantly heightened ( P < 0.05) splenocyte proliferation, increased interleukin‐10, interferon gamma and interleukin‐17 responses, leucocyte phagocytic ability and increased secretory‐immunoglobulin A. However, four‐fold increase in IgG titres to Hepatitis‐B vaccine was observed only in those mice that were supplemented with synbiotic postweaning (F1 Syn+). CONCLUSION Synbiotic supplementation to pregnant dams affected the offspring's cellular and mucosal immunity favorably. However, IgG response to Hepatitis‐B vaccine was influenced positively only when the supplementation was extended to the offsprings in the post weaning period. © 2016 Society of Chemical Industry