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Carrot juice ingestion attenuates high fructose‐induced circulatory pro‐inflammatory mediators in weanling Wistar rats
Author(s) -
Mahesh Malleswarapu,
Bharathi Munugala,
Raja Gopal Reddy Mooli,
Pappu Pranati,
Putcha Uday Kumar,
Vajreswari Ayyalasomayajula,
Jeyakumar Shanmugam M
Publication year - 2016
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.7906
Subject(s) - weanling , medicine , endocrinology , adipose tissue , insulin resistance , fructose , ingestion , carrot juice , inflammation , white adipose tissue , glucose homeostasis , biology , insulin , chemistry , food science
Abstract BACKGROUND Adipose tissue, an endocrine organ, plays a vital role not only in energy homeostasis, but also in the development and/or progression of various metabolic diseases, such as insulin resistance, type 2 diabetes and non‐alcoholic fatty liver disease ( NAFLD ), via several factors and mechanisms, including inflammation. This study tested, whether carrot juice administration affected the adipose tissue development and its inflammatory status in a high fructose diet‐induced rat model. For this purpose, male weanling Wistar rats were divided into four groups and fed either control or high fructose diet of AIN‐93G composition with or without carrot juice ingestion for an 8 week period. RESULTS Administration of carrot juice did not affect the adiposity and cell size of visceral fat depot; retroperitoneal white adipose tissue ( RPWAT ), which was corroborated with unaltered expression of genes involved in adipogenic and lipogenic pathways. However, it significantly reduced the high fructose diet‐induced elevation of plasma free fatty acid ( FFA ) ( P ≤ 0.05), macrophage chemoattractant protein 1 ( MCP1 ) ( P ≤ 0.01) and high sensitive C‐reactive protein ( hsCRP ) ( P ≤ 0.05) levels. CONCLUSION Carrot juice administration attenuated the high fructose diet‐induced elevation of levels of circulatory FFA and pro‐inflammatory mediators; MCP1 and hsCRP without affecting the adiposity and cell size of visceral fat depot; RPWAT . © 2016 Society of Chemical Industry