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Short‐ and long‐term antihypertensive effect of egg protein‐derived peptide QIGLF
Author(s) -
Yu Zhipeng,
Zhao Wenzhu,
Ding Long,
Wang Yaqi,
Chen Feng,
Liu Jingbo
Publication year - 2016
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.7762
Subject(s) - captopril , blood pressure , in vivo , oral administration , pharmacology , angiotensin converting enzyme , renin–angiotensin system , endocrinology , kidney , medicine , angiotensin ii , enzyme , ace inhibitor , chemistry , biochemistry , biology , microbiology and biotechnology
BACKGROUND The present study aimed to investigate the in vivo antihypertensive effect on spontaneously hypertensive rats ( SHRs ) induced by egg protein‐derived peptide QIGLF , which has been previously characterized in vitro as a potent angiotensin‐converting enzyme inhibitor. RESULTS In vivo antihypertensive effect of QIGLF orally administered was evaluated by the tail‐cuff method. The systolic blood pressure and the diastolic blood pressure of rats were measured 0, 5, 10, 15 and 20 h after administration every day. Subsequently, the effect of QIGLF on angiotensin‐converting enzyme mRNA expression in the kidney of SHRs was evaluated by a polymerase chain reaction. Systolic blood pressure was found to be reduced markedly in the SHRs after a single oral administration. CONCLUSION The results show that the effect of QIGLF (50 mg kg −1 body weight) was similar to that of captopril (10 mg kg −1 body weight) with respect to lowering systolic blood pressure in SHRs . Therefore, egg white protein‐derived peptide QIGLF may be useful in the prevention or treatment of hypertension. © 2016 Society of Chemical Industry