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Long‐term toxicity study on genetically modified corn with cry1Ac gene in a Wuzhishan miniature pig model
Author(s) -
Chen Liang,
Sun Zhe,
Liu Quanwei,
Zhong Ruqing,
Tan Shuyi,
Yang Xiaoguang,
Zhang Hongfu
Publication year - 2016
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.7624
Subject(s) - cry1ac , biology , bacillus thuringiensis , miniature pig , genetically modified maize , transgene , genetically modified organism , immune system , zoology , toxicity , microbiology and biotechnology , genetically modified crops , veterinary medicine , gene , immunology , medicine , genetics , bacteria
BACKGROUND The objective of the present study was to investigate the chronic effect of transgenic maize lines by the insertion of the cry1Ac gene from Bacillus thuringiensis (Bt) on the growth performance, immune response and health using a Wuzhishan miniature pig model through a 196‐day feeding study. RESULTS Based on the gender and weight, 72 Wuzhishan miniature pigs were randomly assigned one of the diets containing 65% non‐transgenic isogenic corn or Bt corn at three stages of growth (day 0–69, 70–134 and 135–196). The potential toxicological effects of transgenic corn on pigs were explored. No difference between the diet treatments for growth performance and haematology parameters at any stages of growth. Although subtle differences in serum content of alanine aminotransferase, relative kidney weight and some immune response were observed between the Bt group and isogenic group, they were not considered as diet treatment‐related. CONCLUSION Long‐term feeding Bt corn carrying cry1Ac genes to Wuzhishan miniature pigs did not indicate adverse effects on the growth, immune response and health indicators at any stages of growth. © 2016 Society of Chemical Industry