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Effects of an equol‐producing bacterium isolated from human faeces on isoflavone and lignan metabolism in mice
Author(s) -
Tamura Motoi,
Hori Sachiko,
Nakagawa Hiroyuki,
Yamauchi Satoshi,
Sugahara Takuya
Publication year - 2016
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.7490
Subject(s) - lignan , equol , human feces , bacteria , feces , food science , chemistry , metabolism , biology , daidzein , microbiology and biotechnology , biochemistry , genistein , endocrinology , organic chemistry , genetics
BACKGROUND Equol is a metabolite of daidzein that is produced by intestinal microbiota. The oestrogenic activity of equol is stronger than daidzein. Equol‐producing bacteria are believed to play an important role in the gut. The rod‐shaped and Gram‐positive anaerobic equol‐producing intestinal bacterium Slackia TM ‐30 was isolated from healthy human faeces and its effects on urinary phyto‐oestrogen, plasma and faecal lipids were assessed in adult mice. RESULTS The urinary amounts of equol in urine were significantly higher in mice receiving the equol‐producing bacterium TM ‐30 ( BAC ) group than in the control ( CO ) group ( P < 0.05). However, no significant differences were observed between the urinary amounts of daidzein, dihydrodaidzein, enterodiol, and enterolactone between the BAC and CO groups. No significant differences in the plasma lipids were observed between the two groups. The lipid content (% dry weight) in the faeces sampled on the final day of the experiment tended to be higher in the BAC group than in the CO group ( P = 0.07). CONCLUSION Administration of equol‐producing bacterium TM ‐30 affected the urinary amounts of phyto‐oestrogens and the faecal lipid contents of mice. The equol‐producing bacterium TM ‐30 likely influences the metabolism of phyto‐oestrogen via changes in the gastrointestinal environment. © 2015 Society of Chemical Industry