Premium
Ingenane‐type diterpene compounds from Euphorbia kansui modulate IFN ‐γ production through NF‐κB activation
Author(s) -
Oh Sehyun,
Oh Hyun Woo,
Lee HaReum,
Yoon Sun Young,
Oh SeiRyang,
Ko YoungEun,
Yoo Nina,
Jeong Jinseon,
Kim Jae Wha
Publication year - 2016
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.7380
Subject(s) - secretion , nf κb , biology , biochemistry , chemistry , microbiology and biotechnology , signal transduction
BACKGROUND Euphorbia kansui , a traditional medical herb, has been shown to have anti‐tumour and anti‐viral activities. Previously, we have reported that E. kansui increases interferon‐gamma ( IFN ‐γ) production in natural killer ( NK ) cells. However, it is not clear how E. kansui regulates IFN ‐γ secretion by NK cells. RESULTS In this study, E. kansui was separated into six individual compounds from the same chloroform fraction so that the activity of each compound could be compared. E. kansui compounds induced IFN ‐γ secretion through the phosphorylation of protein kinase D and IκB kinase pathways. Furthermore, E. kansui compounds activated the translocation of p65, a sub‐unit of nuclear factor kappa‐light‐chain‐enhancer of activated B cells ( NF‐κB ), to the nucleus and induced NF‐κB at the transcriptional level. CONCLUSION These findings suggest that E. kansui enhances IFN ‐γ secretion through the NF‐κB pathway in NK cells. © 2015 Society of Chemical Industry