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Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose‐induced metabolic syndrome rats
Author(s) -
Ajiboye Taofeek O,
Raji Hikmat O,
Adeleye Abdulwasiu O,
Adigun Nurudeen S,
Giwa Oluwayemisi B,
Ojewuyi Oluwayemisi B,
Oladiji Adenike T
Publication year - 2015
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.7254
Subject(s) - hibiscus sabdariffa , fructose , insulin resistance , medicine , endocrinology , chemistry , dyslipidemia , glutathione , glutathione peroxidase , glutathione reductase , metabolic syndrome , malondialdehyde , antioxidant , insulin , superoxide dismutase , biochemistry , biology , diabetes mellitus , food science , enzyme
BACKGROUND The effect of Hibiscus sabdariffa calyx extract was evaluated in high‐fructose‐induced metabolic syndrome rats. Insulin resistance, hyperglycemia, dyslipidemia and oxidative rout were induced in rats using high‐fructose diet. High‐fructose diet‐fed rats were administered 100 and 200 mg kg −1 body weight of H. sabdariffa extract for 3 weeks, starting from week 7 of high‐fructose diet treatment. RESULTS High‐fructose diet significantly ( P < 0.05) increased the serum levels of blood glucose, insulin, total cholesterol ( TC ), triacylglycerol ( TAG ), low‐density lipoprotein cholesterol ( LDLc ) and very‐low‐density lipoprotein cholesterol ( VLDLc ), with a concomitant reduction in high‐density lipoprotein cholesterol ( HDLc ). These alterations were significantly ameliorated by the extract. High‐fructose diet‐mediated decreases in the activities of superoxide dismutase ( SOD ), catalase ( CAT ), glutathione peroxidase ( GSH ‐Px), glutathione reductase ( GSH ‐red) and glucose 6‐phosphate dehydrogenase (Glc 6‐ PD ) were significantly ( P < 0.05) attenuated. Altered levels of reduced glutathione ( GSH ) and glutathione disulfide ( GSSG ) were significantly ( P < 0.05) restored to normal. High‐fructose diet‐mediated increases in the concentrations of malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl and percentage fragmented DNA were significantly ( P < 0.05) lowered by the Hibiscus extract. CONCLUSION Overall, aqueous extract of H. sabdariffa palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in high‐fructose‐induced metabolic syndrome rats. © 2015 Society of Chemical Industry