z-logo
Premium
Bioactive quinone derivatives from the marine brown alga Sargassum thunbergii induce anti‐adipogenic and pro‐osteoblastogenic activities
Author(s) -
Kim JungAe,
Karadeniz Fatih,
Ahn ByulNim,
Kwon Myeong Sook,
Mun OkJu,
Bae Min Joo,
Seo Youngwan,
Kim Mihyang,
Lee SangHyeon,
Kim Yuck Yong,
MiSoon Jang,
Kong ChangSuk
Publication year - 2016
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.7148
Subject(s) - adipogenesis , osteocalcin , osteoblast , alkaline phosphatase , chemistry , peroxisome , osteoporosis , bone morphogenetic protein 2 , medicine , microbiology and biotechnology , sargassum , endocrinology , biochemistry , biology , adipose tissue , receptor , botany , in vitro , enzyme , algae
BACKGROUND Health problems related to the lack of bone formation are a major problem for ageing populations in the modern world. As a part of the ongoing trend to develop natural substances that attenuate bone loss in osteoporosis, the effects of the edible brown alga Sargassum thunbergii and its active contents on adipogenic differentiation in 3T3‐L1 fibroblasts and osteoblast differentiation in MC3T3‐E1 pre‐osteoblasts were evaluated. RESULTS Treatment with S. thunbergii significantly reduced lipid accumulation and expression of adipogenic differentiation markers such as peroxisome proliferator‐activated receptor γ, CCAAT /enhancer‐binding protein α and sterol regulatory element binding protein 1c. In addition, S. thunbergii successfully enhanced osteoblast differentiation as indicated by increased alkaline phosphatase activity along raised levels of osteoblastogenesis indicators, namely bone morphogenetic protein‐2, osteocalcin and collagen type I. Two compounds, sargaquinoic and sargahydroquinoic acid, were isolated from active extract and shown to be active by means of osteogenesis inducement. CONCLUSION S. thunbergii could be a source for functional food ingredients for improved treatment of osteoporosis and obesity. © 2015 Society of Chemical Industry

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here