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Diosgenin reorganises hyperglycaemia and distorted tissue lipid profile in high‐fat diet–streptozotocin‐induced diabetic rats
Author(s) -
Naidu Parim Brahma,
Ponmurugan Ponnusamy,
Begum Mustapha Sabana,
Mohan Karthick,
Meriga Balaji,
RavindarNaik Ramavat,
Saravanan Ganapathy
Publication year - 2015
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.7057
Subject(s) - medicine , endocrinology , insulin resistance , diabetes mellitus , diosgenin , streptozotocin , insulin , lipid profile , cholesterol , chemistry , organic chemistry
BACKGROUND Diabetes is often connected with significant morbidity, mortality and also has a pivotal role in the development of cardiovascular diseases. Diet intervention, particularly naturaceutical antioxidants have anti‐diabetic potential and avert oxidative damage linked with diabetic pathogenesis. The present study investigated the effects of diosgenin, a saponin from fenugreek, on the changes in lipid profile in plasma, liver, heart and brain in high‐fat diet–streptozotocin ( HFD‐STZ )‐induced diabetic rats. Diosgenin was administered to HFD‐STZ induced diabetic rats by orally at 60 mg kg −1 body weight for 30 days to assess its effects on body weight gain, glucose, insulin, insulin resistance and cholesterol, triglycerides, free fatty acids and phospholipids in plasma, liver, heart and brain. RESULTS The levels of body weight, glucose, insulin, insulin resistance, cholesterol, triglycerides, free fatty acids, phospholipids, VLDL ‐C and LDL ‐C were increased significantly ( P < 0.05) whereas HDL ‐C level decreased in the HFD / STZ diabetic rats. Administration of diosgenin to HFD‐STZ diabetic rats caused a decrease in body weight gain, blood glucose, insulin, insulin resistance and also it modulated lipid profile in plasma and tissues. CONCLUSION The traditional plant fenugreek and its constituents mediate its anti‐diabetic potential through mitigating hyperglycaemic status, altering insulin resistance by alleviating metabolic dysregulation of lipid profile in both plasma and tissues. © 2014 Society of Chemical Industry