Premium
Maternal exposure to diets containing flaxseed flour or flaxseed oil during pregnancy and lactation protects the aortic remodeling in adult male offspring of diabetic rat dams
Author(s) -
Vicente Gabriela Câmara,
CorreiaSantos André Manoel,
Suzuki Akemi,
Coca Velarde Luis Guillermo,
Chagas Maurício Alves,
Boaventura Gilson Teles
Publication year - 2015
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.7041
Subject(s) - offspring , endocrinology , pregnancy , medicine , diabetes mellitus , aorta , lactation , cholesterol , high density lipoprotein , biology , genetics
BACKGROUND Diabetes during pregnancy is associated with cardiovascular complications in the fetus and extends into adulthood. Therapeutic applications of flaxseed have been studied in cardiovascular disorders, because its oilseed is the best plant source of omega‐3 fatty acid, which is currently considered by researchers to be an essential protective against cardiovascular disease. The aim of this study was to evaluate the influence of flaxseed flour and oil on cardiovascular biochemical parameters and the histoarchitecture of the aorta in adult rats which were offspring of diabetic mothers. RESULTS At 100 days of age in offspring it was observed that maternal consumption of a high‐fat diet containing flaxseed oil ( FOG ) and flaxseed flour ( FFG ) did not affect the serum concentration of monocyte chemoattractant protein‐1, vascular endothelial growth factor, cholesterol, triglycerides, high‐density‐, low‐density‐ or very‐low‐density‐lipoprotein cholesterol. However, the thickness of the intima media layer of the aorta was significantly smaller in FOG and FFG groups; the lumen area was similar among the groups; and a higher percentage of elastic fiber was found in FOG and FFG groups. CONCLUSION These data suggest that the use of both flaxseed flour and its oil reduces the remodeling of the aorta; however; it has not been possible to modify the cardiovascular biochemical parameters. © 2014 Society of Chemical Industry