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Anti‐diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat‐rich combination diet
Author(s) -
Cheng Qian,
Zhang Xiaofeng,
Wang Ou,
Liu Jia,
Cai Shengbao,
Wang Ruojun,
Zhou Feng,
Ji Baoping
Publication year - 2014
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.6737
Subject(s) - diabetes mellitus , fructose , glucokinase , chemistry , glycogen , endocrinology , antioxidant , fatty liver , functional food , medicine , phytotherapy , lipid metabolism , food science , biochemistry , alternative medicine , disease , pathology
BACKGROUND Rhizoma dioscorea , Lycium barbarum , Prunella vulgaris and hawthorn are well known in both traditional food and folk medicine. Each of these plants reportedly possesses beneficial effects in the treatment of diabetes. In this study an anti‐diabetic health‐promoting diet was formulated by mixing the herbs in a ratio of 6:4:2:3, and the anti‐diabetic effect and underlying mechanism were elucidated in vivo . RESULTS Compared with the model control group, the formula, especially its ethanol extract ( EF ), could improve glucose intolerance and normalize the lipid profile. The mechanisms responsible for the amelioration of glucose and lipid metabolism in mice were an increase in peripheral and hepatic insulin sensitivity, a decrease in serum free fatty acid level, enhanced hepatic glucokinase activity and glycogen content and improved serum antioxidant activity. Hepatic histopathological examination also showed that EF administration markedly decreased fatty deposits in the liver of mice. CONCLUSION The results of the present study demonstrated that the prepared functional formula diet is a potent alternative as an anti‐diabetic health‐promoting diet. © 2014 Society of Chemical Industry