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Antihyperglycemic, hypolipidemic, hepatoprotective and antioxidative effects of dietary clove ( Szyzgium aromaticum ) bud powder in a high‐fat diet/streptozotocin‐induced diabetes rat model
Author(s) -
Adefegha Stephen A,
Oboh Ganiyu,
Adefegha Omowunmi M,
Boligon Aline A,
Athayde Margareth L
Publication year - 2014
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.6617
Subject(s) - streptozotocin , syzygium , superoxide dismutase , alkaline phosphatase , antioxidant , diabetes mellitus , catalase , endocrinology , medicine , ascorbic acid , hyperlipidemia , triglyceride , chemistry , oxidative stress , cholesterol , traditional medicine , food science , biochemistry , enzyme
BACKGROUND Syzygium aromaticum (L.) Merr. & Perry (clove) bud is an important spice used in the preparation of several delicacies and in folklore for diabetes management. The present study was convened to assess the effects of dietary clove bud powder ( CBP ) on biochemical parameters in a type 2 diabetes rat model, induced by a combination of high‐fat diet and low‐dose streptozotocin (35 mg kg −1 ) for 30 days . RESULTS Diabetic rats were placed on dietary regimen containing 20–40 g kg −1 clove bud powder. The results revealed that there was no significant ( P > 0.05) difference in the average feed intake and weight changes between the rat groups. Furthermore, supplementation with CBP gradually reduced blood glucose level in diabetic rat compared to control diabetic rats without CBP supplementation ( DBC ). Moreover, reduced activity of α‐glucosidase was observed in CBP and metformin‐treated rat groups when compared to that of the DBC rat group. In addition, the DBC group had significantly ( P < 0.05) higher lipid concentrations (except for high‐density lipoprotein cholesterol) when compared to all other groups. Furthermore, CBP had significantly ( P < 0.05) reduced activity of liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and showed elevated levels of antioxidant status (glutathione, ascorbic acid, superoxide dismutase and catalase) . CONCLUSION The results suggest that the clove bud diet may attenuate hyperglycemia, hyperlipidemia, hepatotoxicity and oxidative stress in the type 2 diabetic condition. © 2014 Society of Chemical Industry