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Bioactive stilbenes from Vitis vinifera grapevine shoots extracts
Author(s) -
Chaher Nassima,
Arraki Kamel,
Dillinseger Elsa,
Temsamani Hamza,
Bernillon Stéphane,
Pedrot Eric,
Delaunay JeanClaude,
Mérillon JeanMichel,
Monti JeanPierre,
Izard JeanClaude,
Atmani Djebbar,
Richard Tristan
Publication year - 2013
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.6341
Subject(s) - vitis vinifera , resveratrol , shoot , piceatannol , chemistry , vitaceae , botany , biochemistry , biology
BACKGROUND Viticultural residues from commercial viticultural activities represent a potentially important source of bioactive stilbenes such as resveratrol. The main aim of the present study was therefore to isolate, identify and perform biological assays against amyloid‐β peptide aggregation of original stilbenes from Vitis vinifera shoots.RESULTS A new resveratrol oligomer, ( Z )‐ cis ‐miyabenol C (3), was isolated from Vitis vinifera grapevine shoots together with two newly reported oligostilbenes from Vitis vinifera shoots, vitisinol C (1) and ( E )‐ cis ‐miyabenol C (2), and six known compounds: piceatannol, resveratrol, ( E )‐ ε ‐viniferin ( trans‐ε ‐viniferin), ω ‐viniferin, vitisinol C and ( E )‐miyabenol C. The structures of these resveratrol derivatives were established on the basis of detailed spectroscopic analysis including nuclear magnetic resonance experiments. All the newly reported compounds were tested for their anti‐aggregative activity against amyloid‐β fibril formation. Vitisinol C was found to exert a significant activity against amyloid‐β aggregation.CONCLUSION Vitis vinifera grapevine shoots are potentially interesting as a source of new bioactive stilbenes, such as vitisinol C. © 2013 Society of Chemical Industry