z-logo
Premium
Anti‐obesity and hypolipidaemic effects of Nelumbo nucifera seed ethanol extract in human pre‐adipocytes and rats fed a high‐fat diet
Author(s) -
You Jeong Soon,
Lee Yun Ju,
Kim Kyung Soo,
Kim Sung Hoon,
Chang Kyung Ja
Publication year - 2014
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.6297
Subject(s) - endocrinology , leptin , adipose tissue , medicine , triglyceride , adipogenesis , glut4 , in vivo , obesity , adipocyte , biology , chemistry , in vitro , biochemistry , insulin resistance , cholesterol , microbiology and biotechnology
BACKGROUND We conducted this investigation in order to examine the anti‐obesity and hypolipidaemic effects of Nelumbo nucifera seed ethanol extract ( NSEE ) in vitro and in vivo .METHODS To study the anti‐obesity effect of NSEE in vitro and in vivo , human pre‐adipocytes were treated with NSEE , and male Sprague–Dawley rats were fed with a normal diet and a high‐fat diet with or without NSEE , respectively.RESULTS In vitro treatment with NSEE resulted in inhibition of lipid accumulation and decreased expression of peroxisome proliferator‐activated receptor gamma ( PPARγ ), glucose transporter 4 ( GLUT4 ), and leptin in cultured human adipocytes, indicating that it inhibited the differentiation of pre‐adipocytes into adipocytes. Administration of NSEE resulted in significantly reduced body weight gain and adipose tissue weights in rats. Serum triglyceride and leptin level of the high‐fat diet + NSEE group was significantly lower, compared to the high‐fat group.CONCLUSION These results demonstrate an inhibitory effect of NSEE on adipogenesis. In addition, NSEE had a beneficial effect, reducing adipose tissue weights, ameliorating blood lipid profile, and modulating serum leptin level in rats fed a high‐fat diet. Therefore, we suggest that lotus seed has a potential to be developed as an effective agent against obesity‐related diseases. © 2013 Society of Chemical Industry

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here